Detalhe da pesquisa
1.
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer.
Cell
; 184(2): 384-403.e21, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33450205
2.
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
Mol Cell
; 70(2): 265-273.e8, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656923
3.
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Genes Dev
; 32(3-4): 309-320, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29491137
4.
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Nature
; 543(7647): 733-737, 2017 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329763
5.
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Nature
; 473(7346): 230-3, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21562564
6.
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Nature
; 459(7249): 1000-4, 2009 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19536265
7.
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Nat Med
; 13(1): 70-7, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17173050
8.
Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
Sci Transl Med
; 16(728): eade2774, 2024 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170787
9.
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.
J Exp Med
; 204(8): 1825-35, 2007 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17646408
10.
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Cancer Discov
; 12(2): 522-541, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34615655
11.
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer.
Nat Commun
; 11(1): 2089, 2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350277
12.
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Nat Commun
; 10(1): 137, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635584
13.
Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.
EBioMedicine
; 39: 215-225, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30581150
14.
Targeting splicing abnormalities in cancer.
Curr Opin Genet Dev
; 48: 67-74, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29136527
15.
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.
Cell Rep
; 23(1): 282-296.e4, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617667
16.
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
Cancer Cell
; 33(3): 386-400.e5, 2018 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29478914
17.
Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
JCI Insight
; 3(19)2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30282833
18.
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
J Med Chem
; 61(18): 8120-8135, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137981
19.
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer Cell
; 34(2): 225-241.e8, 2018 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107174
20.
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Nat Med
; 24(4): 497-504, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457796